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Abstract Longitudinal studies with binary or ordinal responses are widely encountered in various disciplines, where the primary focus is on the temporal evolution of the probability of each response category. Traditional approaches build from the generalized mixed effects modeling framework. Even amplified with nonparametric priors placed on the fixed or random effects, such models are restrictive due to the implied assumptions on the marginal expectation and covariance structure of the responses. We tackle the problem from a functional data analysis perspective, treating the observations for each subject as realizations from subject-specific stochastic processes at the measured times. We develop the methodology focusing initially on binary responses, for which we assume the stochastic processes have Binomial marginal distributions. Leveraging the logits representation, we model the discrete space processes through continuous space processes. We utilize a hierarchical framework to model the mean and covariance kernel of the continuous space processes nonparametrically and simultaneously through a Gaussian process prior and an Inverse-Wishart process prior, respectively. The prior structure results in flexible inference for the evolution and correlation of binary responses, while allowing for borrowing of strength across all subjects. The modeling approach can be naturally extended to ordinal responses. Here, the continuation-ratio logits factorization of the multinomial distribution is key for efficient modeling and inference, including a practical way of dealing with unbalanced longitudinal data. The methodology is illustrated with synthetic data examples and an analysis of college students’ mental health status data. 

Development of a flexible Erlang mixture model for survival analysis is introduced. The model for the survival density is built from a structured mixture of Erlang densities, mixing on the integer shape parameter with a common scale parameter. The mixture weights are constructed through increments of a distribution function on the positive real line, which is assigned a Dirichlet process prior. The model has a relatively simple structure, balancing flexibility with efficient posterior computation. Moreover, it implies a mixture representation for the hazard function that involves time-dependent mixture weights, thus offering a general approach to hazard estimation. Extension of the model is made to accommodate survival responses corresponding to multiple experimental groups, using a dependent Dirichlet process prior for the group-specific distributions that define the mixture weights. Model properties, prior specification, and posterior simulation are discussed, and the methodology is illustrated with synthetic and real data examples. 

Abstract We develop a prior probability model for temporal Poisson process intensities through structured mixtures of Erlang densities with common scale parameter, mixing on the integer shape parameters. The mixture weights are constructed through increments of a cumulative intensity function which is modeled nonparametrically with a gamma process prior. Such model specification provides a novel extension of Erlang mixtures for density estimation to the intensity estimation setting. The prior model structure supports general shapes for the point process intensity function, and it also enables effective handling of the Poisson process likelihood normalizing term resulting in efficient posterior simulation. The Erlang mixture modeling approach is further elaborated to develop an inference method for spatial Poisson processes. The methodology is examined relative to existing Bayesian nonparametric modeling approaches, including empirical comparison with Gaussian process prior based models, and is illustrated with synthetic and real data examples.